Extraordinary Effect of Microwave Irradiation on Catalytic Organic Syntheses

微波辐射对催化有机合成的非凡效果

• 批准号: 23655089
• 负责人: YAMADA Toru
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23655089/
• 关键词: 合成化学; 触媒・化学プロセス; マイクロ波; 選択的合成; 不斉合成

We here report the effect of microwave irradiation on the atropo-enantioselective ring-opening reaction of biaryl lactones with dynamickinetic resolution catalyzed by AgBF_4phosphine complexes. The multimode microwave reactor with a cooling system was employed and the fiber-optic sensor was used for measurement of the accurate internal reaction temperature. It was found that the reaction was accelerated by microwave irradiation without any loss of enantioselectivity at almost the same internal temperature as the conventional conditions. On the basis of Arrhenius plots on the present reaction, it was confirmed that the microwave effect was not only their simple heating effect.

我们在这里报告了微波辐照对双乳酮与AGBF_4磷酸复合物催化的动力学分辨率的双乳酸内酮的抗逆性环反应反应的影响。使用带有冷却系统的多模微波反应器，并将光纤传感器用于测量准确的内部反应温度。发现该反应是通过微波辐照加速的，而在几乎与常规条件的内部温度几乎相同的内部温度下，对对映选择性的丧失。根据当前反应的Arrhenius图，可以证实微波效应不仅是它们的简单加热效果。

项目成果

ビアリールラクトンの触媒的アトロプ不斉メタノリシス反応におけるマイクロ波照射による加速効果

微波辐射对联芳基内酯催化阿托对称甲醇解反应的加速作用

• 发表时间: 2012
• 作者: Takuya Iida;Shimpei Hidaka;Yojiro Yamamoto;Shiho Tokonami,;Ilhyong Ryu;主代和也・菊地哲・山田徹
• 通讯作者: 主代和也・菊地哲・山田徹