Reversible photoregulaton of microtubule dynamics and development of artificial bio-molecular machines

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In this study, we tried to synthesize novel azobenzene derivatives, which can reversibly regulate the microtubule depolymerization-polymerization dynamics with external light stimuli, and attempted to develop artificial bio-molecular machines. For such purpose, we prepared several azobenzene derivatives having different kinds of substituent with different positions and rigorously investigated the effect on the microtubule polymerization dynamics. From detailed investigations, it was revealed that the amphiphilic structure of azobenzene was essential to achieve the reversible photoregulation of microtubule polymerization dynamics.