Development of a radioactive low-molecular weight probe for the specific imaging of HIF-1-active hypoxic tumors
Development of a radioactive low-molecular weight probe for the specific imaging of HIF-1-active hypoxic tumors
批准号:
23791412
负责人:
UEDA Masashi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
缺氧诱导因子-1(HIF-1)在恶性肿瘤的进展和放疗抵抗的发展中起重要作用。为了对HIF-1活性肿瘤成像,设计并合成了一种肽探针(Δ I-DKOP 30),其含有HIF-1 α氧依赖性降解的必需序列。在缺氧细胞中,DKOP 30的蓄积量高于常氧细胞。生物分布分析显示,在肿瘤中积累了14 I-DKOP 30。通过体内成像可以清楚地观察到肿瘤,并且肿瘤内^I-DKOP 30的分布与HIF-1a阳性缺氧区域一致。因此,1-DKOP 30是用于HIF-1活性肿瘤成像的有用肽探针。
英文摘要
Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumor progression and in the development of resistance to radiotherapy. To image HIF-1-active tumors, a peptide probe (^I-DKOP30) was designed and synthesized that contains an essential sequence of the oxygen-dependent degradation of HIF-1a. ^I-DKOP30 showed higher accumulation in hypoxic cells than normoxic cells. Biodistribution analysis showed ^I-DKOP30 accumulation in tumors. The tumors were clearly visualized by in vivoimaging, and intratumoral distribution of ^I-DKOP30 coincided with the HIF-1a-positive hypoxic regions. Thus, ^I-DKOP30 is a useful peptide probe for the imaging of HIF-1-active tumors.
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Visualization and Treatment of the HIF-1-Active Microenvironments in Tumors: Drug Design and Application of Oxygen-dependent Degradable Probes for Molecular Imaging of HIF-1-active Microenvironments. In: Hypoxia: Causes, Types and Management, Dirk Vorderm
肿瘤中 HIF-1 活性微环境的可视化和治疗:用于 HIF-1 活性微环境分子成像的氧依赖性可降解探针的药物设计和应用。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Ueda M, Saji H]
通讯作者:
Saji H
低酸素腫瘍イメージングを目的とした低酸素特異的安定型ペプチドプローブの開発に関する基礎的検討
低氧特异性稳定肽探针开发用于低氧肿瘤成像的基础研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小川京, 上田真史, 他]
通讯作者:
他
HIF-1酸素依存的分解配列を利用した低酸素腫瘍イメージングペプチドプローブの開発
利用 HIF-1 氧依赖性降解序列开发缺氧肿瘤成像肽探针
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小川京, 上田真史, 大島譲介, 福島隆宏, 小野正博, 佐治英郎]
通讯作者:
佐治英郎
Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1alpha-active regions in tumors
开发用于肿瘤缺氧诱导因子-1α活性区域成像的氧敏感可降解肽探针
DOI:
--
发表时间:
2013
期刊:
Molecular Imaging and Biology
影响因子:
3.1
作者:
[Ueda M, Ogawa K, Miyano A, Ono M, Kizaka-Kondoh S, Saji H]
通讯作者:
Saji H
放射性ヨウ素により標識された標識化合物
用放射性碘标记的标记化合物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 13 条
Development of an imaging probe targeting receptor for advanced glycation end-products (RAGE): Challenge to overcoming false-positive results of amyloid PET
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批准号:16K15583
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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Feasibility evaluation of central nicotinic acetylcholine receptors as an imaging biomarker of cognitive function
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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财政年份:2014
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负责人:UEDA Masashi
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Development of the high-sensitive imaging method for HIF-1-active hypoxic tumors based on the metabolic trapping approach
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批准号:21791187
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2009
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负责人:UEDA Masashi
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依托单位:
Elucidation of brain regions related to antiallodynic effects based on the molecular imaging of cholinergic nerve function under neuropathic pain conditions
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批准号:19790869
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.26万
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财政年份:2007
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负责人:UEDA Masashi
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依托单位:
海外基金