Development of a dose calculation method and a treatment planning system for radiotherapy based on the Boltzmann transport equation

该项目的目的是为最先进的癌症放疗开发一个快速准确的剂量计算代码和基于它的治疗计划优化系统。虽然我们不能完成剂量计算代码的开发，但我们通过对小领域的调查，揭示了新剂量计算代码应满足的必要条件，而通常的剂量计算方法的不确定性可能很大。对于治疗方案的优化，我们提出了剂量不确定度的评价方法，这是使剂量不确定度最小化所必需的。我们还开发了运动肿瘤的剂量计算方法，可用于考虑肿瘤运动的优化。

The purpose of the project was to develop a fast and accurate dose calculation code for the state-of-the-art radiotherapy of cancer and a treatment planning optimization system based on it. While we could not complete the development of the dose calculation code, we revealed the necessary conditions which should be satisfied by the new dose calculation code by investigating small fields, where the uncertainty of usual dose calculation methods can be large. As for the optimization for treatment planning, we developed the method of the evaluation of dose uncertainty, which is necessary for the minimization of dose uncertainty. We also developed the dose calculation method for moving tumors, which can be used for the optimization considering tumor motions.