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Development of new therapeutic artificial virus with the ability of escape from endocytosis

Development of new therapeutic artificial virus with the ability of escape from endocytosis
开发具有逃避内吞作用的新型治疗性人工病毒
批准号:
23791543
负责人:
EGAMI Takuya
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We find out the endocytosis pathway at pancreatic cancer and create an artificial virus contained anti-cancer drug. Pancreatic cancer cells highly expressed integrin β3 more than β5 are decreased expression of adenovirus-transfected gene, and pancreatic cancer cells silencing expression of integrin β 3 showed high expression of adenovirus-transfected gene. We altered an artificial virus silencing integrin β3 by protease signaling
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会议论文
Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells.
腺病毒治疗对吉西他滨耐药的胰腺癌比对吉西他滨敏感的细胞更有效。
DOI: --
发表时间:
期刊: Anticancer research. in press
影响因子: --
作者: [Takaharu Yasui, Kenoki Ohuchida, Ming Zhao, Lin Cui, Manabu Onimaru, Takuya Egami, Hayato Fujita, Takao Ohtsuka, Kazuhiro Mizumoto, Kunio Matsumoto, Masao Tanaka.]
通讯作者: Masao Tanaka.
DOI: 10.1111/j.1349-7006.2010.01783.x
发表时间: 2011-02
期刊: Cancer Science
影响因子: 5.7
作者: [T. Yasui;K. Ohuchida;Ming Zhao;M. Onimaru;Takuya Egami;H. Fujita;T. Ohtsuka;K. Mizumoto;Masao Tanaka]
通讯作者: T. Yasui;K. Ohuchida;Ming Zhao;M. Onimaru;Takuya Egami;H. Fujita;T. Ohtsuka;K. Mizumoto;Masao Tanaka
Development of novel treatment for pancreatic cancer to break through the fibrotic barrier by combining pancreatic stellate cell inhibitors with nanoparticles
  • 批准号:
    20K07661
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.83万
  • 财政年份:
    2020
  • 负责人:
    EGAMI Takuya
  • 依托单位:
The role of autophagy in perineural infiltration of pancreatic cancer
  • 批准号:
    16K10597
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2016
  • 负责人:
    EGAMI Takuya
  • 依托单位:
The improvement of therapy-resistance with modified new virus and application to the treatment in pancreatic cancer
  • 批准号:
    25462119
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.24万
  • 财政年份:
    2013
  • 负责人:
    EGAMI Takuya
  • 依托单位:
Breakthrough in the mechanism of adenoviral gene delivery and new developments to apply the achievement in a clinical setting
  • 批准号:
    21791298
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2009
  • 负责人:
    EGAMI Takuya
  • 依托单位:
海外基金