Development of new therapeutic artificial virus with the ability of escape from endocytosis

开发具有逃避内吞作用的新型治疗性人工病毒

• 批准号: 23791543
• 负责人: EGAMI Takuya
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791543/
• 关键词: エンドサイトーシス; アデノウイルス; 薬剤内包型人工ウイルス; 膵癌; Drug Delibery System

We find out the endocytosis pathway at pancreatic cancer and create an artificial virus contained anti-cancer drug. Pancreatic cancer cells highly expressed integrin β3 more than β5 are decreased expression of adenovirus-transfected gene, and pancreatic cancer cells silencing expression of integrin β 3 showed high expression of adenovirus-transfected gene. We altered an artificial virus silencing integrin β3 by protease signaling

我们发现了胰腺癌的内吞途径，并创造了一种含有抗癌药物的人工病毒。胰腺癌细胞中整合素β3的高表达高于β5，腺病毒转染基因表达降低，而沉默整合素β 3表达的胰腺癌细胞中整合素β 3的表达则呈腺病毒转染基因的高表达。我们改变了一个人工病毒沉默整合素β3蛋白酶信号

项目成果

Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells.

腺病毒治疗对吉西他滨耐药的胰腺癌比对吉西他滨敏感的细胞更有效。

• 期刊: Anticancer research. in press
• 作者: Takaharu Yasui;Kenoki Ohuchida;Ming Zhao;Lin Cui;Manabu Onimaru;Takuya Egami;Hayato Fujita;Takao Ohtsuka;Kazuhiro Mizumoto;Kunio Matsumoto;Masao Tanaka.
• 通讯作者: Masao Tanaka.

Tumor–stroma interactions reduce the efficacy of adenoviral therapy through the HGF‐MET pathway

• DOI: 10.1111/j.1349-7006.2010.01783.x
• 发表时间: 2011-02
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: T. Yasui;K. Ohuchida;Ming Zhao;M. Onimaru;Takuya Egami;H. Fujita;T. Ohtsuka;K. Mizumoto;Masao Tanaka