Analysis of immune response to overcome immune-escape of lung cancer

克服肺癌免疫逃逸的免疫反应分析

• 批准号: 23791580
• 负责人: SHIGEMATSU Yoshiki
• 金额: $ 2.25万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791580/
• 关键词: 肺癌; 腫瘍免疫; 免疫逃避機構; 制御性T細胞; HLA; 制御性Ｔ細胞; TGF-β; Foxp3; 所属リンパ節; HLA class I; Foxp 3; 定量的PCR

The purpose of this study was to evaluate immune response in patients with non-small cell lung cancer (NSCLC) to overcome the tumor immune escape mechanism. The higher proportion of CD4+ CD25+ Foxp3+ regulatory T cells in the regional lymph node was a significant unfavorable prognostic factor, even in patients with node-negative NSCLC. The normal expression of HLA-class I was associated with a favorable prognosis in comparison with the heterogeneous expression group. It is necessary to evaluate the efficacy of adjuvant immunotherapy in consideration of clinical significance of the HLA expression pattern and the proportion of regulatory T cells.

本研究旨在评估非小细胞肺癌（NSCLC）患者的免疫应答，以克服肿瘤免疫逃逸机制。区域淋巴结中较高比例的CD 4 + CD 25 + Foxp 3+调节性T细胞是显著的不利预后因素，即使在淋巴结阴性NSCLC患者中也是如此。HLA-Ⅰ类正常表达者预后较好。有必要考虑HLA表达模式和调节性T细胞比例的临床意义来评估辅助免疫治疗的疗效。

项目成果

肺癌患者における制御性T細胞の発現と役割

调节性T细胞在肺癌患者中的表达及作用

• 发表时间: 2011
• 作者: 重松義紀;黒田耕志;馬場哲郎;竹中賢;近石泰弘;岡壮一;中川誠;下川秀彦;浦本秀隆;宗知子;花桐武志;田中文啓
• 通讯作者: 田中文啓

Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients

• DOI: 10.1007/s10147-012-0491-8
• 发表时间: 2013-12-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Baba, Tetsuro;Shiota, Hironobu;Tanaka, Fumihiro
• 通讯作者: Tanaka, Fumihiro

Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma

• DOI: 10.1093/ejcts/ezs426
• 发表时间: 2013-04-01
• 期刊: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
• 影响因子: 3.4
• 作者: Baba, Tetsuro;Shiota, Hironobu;Tanaka, Fumihiro
• 通讯作者: Tanaka, Fumihiro