Treatment and anticipation of progression of osteoarthritis of knee based on adenosin triphosphate pathway

基于三磷酸腺苷途径的膝骨关节炎治疗及进展预测

• 批准号: 23791642
• 负责人: KUMAHASHI Nobuyuki
• 金额: $ 1.66万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791642/
• 关键词: 変形性膝関節症; 滑膜; アデノシン三リン酸; P2X7受容体; 疼痛; アデノシン三燐酸; 膝痛; P2X受容体; P2Y2受容体

In the human OA groups, the synovial cells were stained positive for P2RX7 receptor in all 14 OA patients; 3 were stained strongly positive on immunohistochemical examination. In the control group, the cells in one of four patients stained positively, but only weakly. There was a significant difference in expression of P2RX7 receptor between the two groups. In addition, the group stained positively advanced OA compared to the one stained strongly.In the rabbit OA models, the deep layer of cartilage matrix was stained more strongly in the HA and oATP+HA groups than in the control group.We conclude that the degree of P2X7 receptor expression in the synovium is associated with OA progression,and that the P2X7 receptor may be involved in the pain mechanism pathway.

在人OA组中，在所有14名OA患者中，P2RX7受体染色阳性。 3对免疫组织化学检查染色呈阳性。在对照组中，四名患者之一的细胞对对照组进行了积极染色，但仅弱染色。两组之间的P2RX7受体表达存在显着差异。此外，与对照组相比，与对照组相比，该小组的染色与强烈的OA相比，在HA和OATP+HA组中对软骨矩阵的深层染色比染色更强。