The role of TROY after the spinal cord injury and application ofTROY for the treatment of injuries of the central nervous system.

TROY在脊髓损伤后的作用及其在中枢神经系统损伤治疗中的应用

• 批准号: 23791655
• 负责人: HISAOKA Tomoko
• 金额: $ 2.66万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791655/
• 关键词: 再生医学; 脊髄損傷; サイトカイン; グリア瘢痕; 嗅神経被覆グリア

First, we investigated the expression pattern of TROY in thedeveloping and adult spinal cord. TROY was expressed in the nestin-positive,GLAST-negative neural progenitor/radial glial cells in the spinal cord during embryonicstages. During postnatal stages, TROY was exclusively expressed in the GFAP- orS100-positive astrocytes in the spinal cord. Next, we investigated the expression ofTROY in the spinal cord after dorsal hemisection of the spinal cord. A few TROY-positivecells were observed around the injury site. These results suggest that TROY may beinvolved in the development of dorsal subpopulation of neural progenitor/radial glialcells and astrocytes in the spinal cord.

首先，我们研究了Troy在发育中和成年脊髓中的表达模式。在胚胎发育过程中，Troy表达于脊髓中巢蛋白阳性、GLAST阴性的神经前体细胞/放射状胶质细胞。在出生后阶段，Troy仅在脊髓内GFAP或S100阳性的星形胶质细胞中表达。接下来，我们研究了脊髓背侧半横断后TROY在脊髓中的表达。损伤部位周围可见少量特洛伊阳性细胞。这些结果提示，Troy可能参与了脊髓内神经前体/放射状胶质细胞和星形胶质细胞的背侧亚群的发育。