The role of TROY after the spinal cord injury and application ofTROY for the treatment of injuries of the central nervous system.

首先，我们研究了TROY在发育和成年脊髓中的表达模式。TROY在胚胎期脊髓中表达于nestin阳性、GLAST阴性的神经前体细胞/放射状胶质细胞。在出生后阶段，TROY只表达于脊髓中GFAP或S100阳性的星形胶质细胞。接下来，我们研究了脊髓背侧半切后TROY在脊髓中的表达。损伤区周围可见少量TROY阳性细胞。这些结果提示，TROY可能参与了脊髓背侧神经前体/放射状胶质细胞和星形胶质细胞亚群的发育。

First, we investigated the expression pattern of TROY in thedeveloping and adult spinal cord. TROY was expressed in the nestin-positive,GLAST-negative neural progenitor/radial glial cells in the spinal cord during embryonicstages. During postnatal stages, TROY was exclusively expressed in the GFAP- orS100-positive astrocytes in the spinal cord. Next, we investigated the expression ofTROY in the spinal cord after dorsal hemisection of the spinal cord. A few TROY-positivecells were observed around the injury site. These results suggest that TROY may beinvolved in the development of dorsal subpopulation of neural progenitor/radial glialcells and astrocytes in the spinal cord.