The role of orphan receptor, TROY, in the proliferation and differentiation of glioma stem cells

我们已经报道了TROY在室管膜下区（SVZ）的GFAP阳性神经干细胞和/或星形胶质细胞祖细胞中表达。在本研究中，我发现，LTα，TROY的配体，表达在这些GFAP阳性细胞在脑室下区（SVZ）的成年小鼠。近年来，有报道称脑肿瘤干细胞可能来源于SVZ的正常神经干细胞或祖细胞。在U251胶质瘤细胞中发现CD 133阳性胶质瘤干细胞表达TROY。这些结果揭示了SVZ中的TROY阳性/GFAP阳性神经干细胞与CNS中的TROY阳性/CD 133阳性胶质瘤干细胞的相关性。

We have reported that TROY was expressed in the GFAP-positive neural stem cells and/or astroglial progenitor cells in the subventricular zone (SVZ). In the present study, I showed that LTα, a ligand of TROY, was expressed in these GFAP-positive cells in the subventricular zone (SVZ) of adult mice. Recently, it has been reported that brain tumor stem cells might be derived from normal neural stem or progenitor cells of the SVZ. I found the expression of TROY in CD133-positive glioma stem cells in U251 glioma cells. These results shed light on the association of TROY-positive/GFAP-positive neural stem cells in the SVZ and TROY-positive/CD133-positive glioma stem cells in the CNS.