Induction of Mesenchymal Stem Cells from Pluripotent Stem Cells

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In this study, we derived the MSCs from rabbit ESCs and human iPSCs both in vivo and in vitro, and examined their detailed characteristics.Both in vivo- and in vitro-pcMSCs expressed MSC-markers and showed multiple differentiation properties. In the cases of the in vitro-pcMSCs, teratoma formations were not observed, and when rabbit ESC-derived in vitro-pcMSCs were transplanted into the model rabbits, successful engraftment were observed. On the other hand, the in vivo-induced MSCs derived from human iPSCs showed high telomerase activity and formed teratomas.We could obtain the MSC-like cells both in vivo and in vitro. However, the present results suggest that pluripotent stem cells could derive various types of MSCs, and we should select the cells carefully based on the appropriate markers for our purposes.