Effects of anesthetic-induced preconditioning on mitochondrial ion channels

点击翻译按钮获取中文摘要

We studied electrophysiological profiles of mitochondrial ion channels, which are known as important factors in anesthetic-induced preconditioning. Calcium overload is crucial mechanism to trigger cardiac ischemia/reperfusion injury. Ryanodine receptors play an important role as a mediator of calcium-induced calcium release in myocytes. We found several types of mitochondrial ion channels, and one of them may be mitochondrial ryanodine receptors. Cardiac sodium current was also recorded. APC resulted in the increase of the sodium current density. This change was correlated with the increase of the sodium channel expression. The steady-state inactivation curve was significantly shifted toward depolarizing direction, and recovery from inactivation was significantly accelerated. These electrophysiological changes by APC did not affect the action potential simulation.