Evaluation for clinical utilization of anti-inflammatory agents in spinal cord ischemia.

抗炎药治疗脊髓缺血的临床应用评价。

• 批准号: 23791707
• 负责人: YAMASHITA Atsuo
• 金额: $ 2.66万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791707/
• 关键词: 脊髄虚血; 遅発性対麻痺; 再灌流障害; 炎症反応; 抗TNF-α抗体; インフリキシマブ; 麻酔科学; 脳・神経科学; 脳・神経; 胸腹部大動脈瘤; 脳・脊髄・神経; 神経保護

We investigated whether the ischemic spinal cord injury in rabbits was reduced by infliximab, an anti- tumor necrosis factor-alpha agent. We assigned rabbits to three groups (n=5, expect high dose infliximab group); a control group, low dose infliximab group (5mg/kg), high dose infliximab group (10mg/kg). Spinal cord ischemia was produced by occluding the abdominal aorta for 15 min. After the reperfusion, hindlimb motor function (score range: 4, normal to 0, paraplegia) was assessed daily for 7 days, and then the number of normal neurons in the anterior spinal cord was counted. There were no significant intergroup differences in neurological scores. On the other hand, the numbers of normal neurons of low dose infliximab group had significantly more than a control group. This results indicate that low dose infliximab(5mg/kg) may protect ischemic spinal cord injury, but clinical utilization of infliximab for spinal cord ischemia should be discreet.

我们研究了英夫利昔单抗（一种抗肿瘤坏死因子-α药物）是否能减轻兔缺血性脊髓损伤。 将家兔随机分为对照组、英夫利西单抗低剂量组（5 mg/kg）、英夫利西单抗高剂量组（10 mg/kg）。 通过阻断腹主动脉15 min造成脊髓缺血。再灌注后，每天评估后肢运动功能（评分范围：4，正常至0，截瘫），持续7 d，然后计数脊髓前部正常神经元的数量。 神经系统评分无显著组间差异。另一方面，低剂量英夫利西单抗组的正常神经元数量显著多于对照组。 提示小剂量英夫利西单抗（5 mg/kg）对缺血性脊髓损伤有保护作用，但临床应用应慎重。

项目成果

山口大学医学部 麻酔科蘇生科ホームページにて、結果を公表予定

结果将在山口大学医学院麻醉与复苏系网站上公布。