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Solution of the antitumor effect and clinical trials of the peptide vaccine therapy for renal cel carcinoma and bladder cancer

Solution of the antitumor effect and clinical trials of the peptide vaccine therapy for renal cel carcinoma and bladder cancer
肽疫苗治疗肾癌和膀胱癌的抗肿瘤效果及临床试验的解决方案
批准号:
23791781
负责人:
OBARA Wataru
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We investigated the predictive factor associated with the effect of the peptide vaccine treatment using clinical specimen. The expression of MPHOSPH1 and DEPDC1 antigen were recognized in all cases, but there was no correlation between expression intensity and grade and stage of the tumor. Cases 80% or more showed CTL induction after vaccination, and the CTL induction was maintained during follow-up period. The patient in recognition of the response of the vaccine administration site showed a decrease of the recurrence rate as compared with an absent case. Performance Status, CTL induction and injection site reaction were identified as an associated factor of the peptide vaccine treatment.
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会议论文
泌尿器がん免疫療法の開発と展望ゲノム解析を基盤としたペプチドワクチン療法の開発と展望
泌尿系肿瘤免疫治疗的进展与展望 基于基因组分析的肽疫苗治疗的进展与展望
DOI: --
发表时间: 2012
期刊: 西日泌尿2012
影响因子: --
作者: [小原航, 藤岡知昭, 吉田浩二, 角田卓也, 中村祐輔]
通讯作者: 中村祐輔
DOI: 10.1093/jjco/hys069
发表时间: 2012-07-01
期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
影响因子: 2.4
作者: [Obara, Wataru, Ohsawa, Ryuji, Fujioka, Tomoaki]
通讯作者: Fujioka, Tomoaki
膀胱癌ペプチドワクチン療法
膀胱癌肽疫苗治疗
DOI: --
发表时间: 2013
期刊: 泌尿器外科
影响因子: --
作者: [小原 航]
通讯作者: 小原 航
DOI: --
发表时间: 2011
期刊: RCC Today
影响因子: --
作者: [小原航, 藤岡知昭]
通讯作者: 藤岡知昭
30
    Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma
    • 批准号:
      20791120
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2008
    • 负责人:
      OBARA Wataru
    • 依托单位:
    海外基金