Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma
Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma
批准号:
20791120
负责人:
OBARA Wataru
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The exogenous vitamin D had no effect for normal kidney cell and showed the activation of the vitamin D metabolic pathway with activity of CYP24. Vitamin D3 had the suppression of the renal carcinoma cell proliferation and the mechanism of action was caused by induction of apoptosis and the cell cycle arrest. Activity of CYP24 also increased by combination of molecular target medicine and vitamin D3 and showed augmentation of the cytostatic effect.
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腎・泌尿器癌-基礎・臨床研究のアップデート I.腎癌 臨床研究 治療 腎癌の分子標的治療 その他の分子標的薬
肾癌/泌尿器官癌-基础/临床研究更新一、肾癌临床研究治疗肾癌分子靶向治疗其他分子靶向药物
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小原航, 藤岡知昭]
通讯作者:
藤岡知昭
Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors
Y染色体上的睾丸特异性蛋白(TSPY)抑制雄激素依赖性睾丸生殖细胞肿瘤中雄激素受体的活性
DOI:
--
发表时间:
2010
期刊:
Proc Natl Acad Sci USA.
影响因子:
--
作者:
[Akimoto, C., Ueda, T., Inoue, K., Yamaoka, I., Sakari, M., Obara, W., Fujioka, T., Nagahara, A., Nonomura, N., Tsutsumi, S., Aburatani, H., Miki, T., Matsumoto, T., Kitagawa, H., Kato, S.]
通讯作者:
S.
Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinom
干扰素-α和活性维生素 D3 联合治疗日本转移性肾细胞癌患者的前瞻性研究
DOI:
--
发表时间:
2008
期刊:
Int J Ural 15・9
影响因子:
--
作者:
[Obara W, et.al.]
通讯作者:
et.al.
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1016/j.juro.2007.05.119
发表时间:
2007-10-01
期刊:
JOURNAL OF UROLOGY
影响因子:
6.6
作者:
[Obara, Wataru, Konda, Ryuichiro, Fujioka, Tomoaki]
通讯作者:
Fujioka, Tomoaki
共 22 条
Solution of the antitumor effect and clinical trials of the peptide vaccine therapy for renal cel carcinoma and bladder cancer
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批准号:23791781
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2011
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负责人:OBARA Wataru
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依托单位:
海外基金