Liposomal IL-21/IL-15 Gene Therapy in an Orthotopic Bladder Cancer Model and Prevention of Tumor Invasion and Metastasis

原位膀胱癌模型中的脂质体IL-21/IL-15基因治疗及预防肿瘤侵袭和转移

• 批准号: 23791788
• 负责人: MATSUSHIMA Masashi
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791788/
• 关键词: 膀胱癌; インターロイキン21; 遺伝子導入; 膀胱内注入; IL-21; IL-15; マウス膀胱癌同所性モデル

We transfected IL-21 plasmid to MBT2 cells, and the supernatant IL-21 level was measured by ELISA after the transfection of IL-21 gene. The peak IL-21level was observed 24 hr after the transfection of IL-21 plasmids. Next, we established the orthotopic bl

将IL-21质粒转染MBT 2细胞，ELISA法检测转染后上清液中IL-21的水平。IL-21质粒转染后24小时观察到IL-21水平的峰值。接下来，我们建立了原位BL