Roles of branched-type disialyl- antigen in malignant conversion in renal cell cancer

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Flow cytometric analysis of RCCs revealed that GalNAc-DSLc4 is presented on the cell surface in 70% of RCC lines. To investigate the roles of GalNAc-DSLc4 antigen in RCC, we prepared GalNAc-DSLc4-overexpressing transfectant cells using VMRC-RCW cells. They showed increased proliferation and invasion activities, and specific adhesion onto laminin-coating plates. These results suggest that GalNAc-DSLc4 is, at least partly, involved in the malignant properties of RCCs. And recently, we found that PI3K inhibitor (LY294002) suppresses malignant phenotype in GalNAc-DSLc4-overexpressing transfectant.