Identification of miRNA and its target gene by proteome analysis in hormone refractory prostate cancer

微rna （miRNAs）调控多种基因，其表达异常导致包括癌症在内的多种疾病。在此之前，我们发现了一些可能与前列腺癌进展相关的mirna。在本研究中，我们发现miR-30d在癌细胞和组织中的表达高于正常前列腺细胞和组织。此外，miR-30d表达与无复发生存率相关。因此miR-30d可能是前列腺癌复发的预后因素。我们发现SOCS1是miR-30d的靶标之一。miR-30对SOCS1的调节与前列腺癌的进展有关。

micro RNAs (miRNAs) regulate many genes and therefore their expression abnormality cause various diseases including cancer. Previously, we identified some miRNAs that might be related with prostate cancer progression. In this study, we found that miR-30d expression in cancer cells and tissues is higher than in normal prostate cells and tissues. Further, miR-30d expression was associated with recurrence free survival ratio. Therefore miR-30d might be a prognosis factor for prostate cancer recurrence. We identified that SOCS1 was one of the targets for miR-30d. SOCS1 regulation by miR-30 was related with prostate cancer progression.