Regenerative therapy in cardiology by human amnion-derived immunotolerant cells in allogeneic combination

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At present, the definitive therapy to patients with severe heart failure is only heart transplantation. However, lack of donor organs is indeed a social problem in the world. We have previously established isolation system of mesenchymal stem cells from amnion, and showed availability of amnion-derived cells as a transplantable biomaterial. Once availability of amnion-derived cells from the viewpoint of regenerative therapy is established, cell source problem must be solved. In this study, we showed long-term survival of amnion-derived cells and elucidate mechanism of in vivo immune tolerance.