Analysis of relations with cSrc and the radiation therapy in head and neck cancer patient

头颈癌患者cSrc与放射治疗的关系分析

• 批准号: 23791939
• 负责人: MATSUMOTO Fumihikoa
• 金额: $ 2.66万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791939/
• 关键词: 頭頸部外科学; cSrc; 放射線; EGFR; IGF1R; 頭頸部扁平上皮癌; 放射線治療

The specimen was obtained by biopsy or surgery from patient was investigated by immunohistochemistry . The patients have high expression level of cSrc is more resistant to radiotherapy than low expression. Furthermore, the combination effect of anti IGF-1R and EGFR antibody and radiotherapy to head and neck cancer cell was examined in xenograft mouse model. The combination of anti-EGFR and IGF-1R and radiation showed high antitumor effect.

采用免疫组织化学方法对经活检或手术获取的标本进行检测。CSRC高表达患者较低表达患者对放射治疗的耐受性更强。此外，在异种移植小鼠模型上观察了抗IGF-1R和EGFR抗体联合放射治疗对头颈部癌细胞的作用。联合应用抗EGFR和IGF-1R联合放射治疗具有较高的抗肿瘤效果。

项目成果

Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro.

• DOI: 10.1158/1078-0432.ccr-10-2120
• 发表时间: 2011-04-01
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Sano D;Matsumoto F;Valdecanas DR;Zhao M;Molkentine DP;Takahashi Y;Hanna EY;Papadimitrakopoulou V;Heymach J;Milas L;Myers JN
• 通讯作者: Myers JN

A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe

• DOI: 10.1007/s10637-009-9361-2
• 发表时间: 2011-06
• 期刊: Investigational New Drugs
• 影响因子: 3.4
• 作者: O. Riesterer;F. Matsumoto;Li Wang;J. Pickett;D. Molkentine;U. Giri;L. Milas;U. Raju

The Impact of Timing of EGFR and IGF-1R Inhibition for Sensitizing

EGFR 和 IGF-1R 抑制时机对致敏的影响

• 发表时间: 2012
• 期刊: Head and Neck Cancer to Radiation. Anticancer Res
• 作者: Matsumoto F;Valdecanas DN;Mason KA;Milas L;Ang KK;Raju U
• 通讯作者: Raju U