Clinical Science Research Core (CSRC)

临床科学研究核心（CSRC）

• 批准号: 9926265
• 负责人: Bettina Mittendorfer
• 金额: $ 30.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9926265
• 关键词: Abbreviations; Adipose tissue; Aerobic; Appearance; Applied Research; Area; Behavior Therapy; Beta Cell; Biopsy Specimen; Blood; Body Composition; Body Weight decreased; Cardiovascular system; Carotid Arteries; Cell Culture Techniques; Cell physiology; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Complex; Consultations; Data; Diet; Dual-Energy X-Ray Absorptiometry; Echocardiography; Endothelium; Energy Metabolism; Ensure; Equilibrium; Exercise; Fatty Acids; Feeding behaviors; Fostering; Glucose; Glucose Clamp; Hormones; Hospitals; Human; Indirect Calorimetry; Infusion procedures; Institutes; Insulin; Intervention; Intervention Studies; Intestines; Intravenous; Isotopes; Kinetics; Life Style; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mass Fragmentography; Measurement; Mediation; Metabolic; Metabolic Clearance Rate; Muscle; Muscle Proteins; OGTT; Obesity; Performance; Physical Performance; Preparation; Procedures; Protein Biosynthesis; Protocols documentation; Regulation; Research; Research Activity; Research Design; Research Personnel; Research Support; Sampling; Schedule; Science; Scientist; Series; Services; Stable Isotope Labeling; State Hospitals; Structure; Taste Perception; Taste preferences; Testing; Tissue Banks; Tissues; Tracer; Training; Translational Research; Universities; Venous; Washington; Weight Gain; behavior test; cardiovascular imaging; clinical center; clinical imaging; cohesion; cost effectiveness; design; exercise training; follower of religion Jewish; hands on instruction; human subject; human tissue; in vivo; insulin secretion; insulin sensitivity; interdisciplinary collaboration; intimal medial thickening; investigator training; lectures; lifestyle intervention; mathematical model; medical schools; multidisciplinary; non-alcoholic fatty liver disease; nutrition; operation; organizational structure; performance tests; recruit; research study; spectroscopic imaging; stable isotope; tissue culture; very low density lipoprotein triglyceride

PROJECT SUMMARY/ABSTRACT- Clinical Science Research Core: The Clinical Science Research Core (CSRC) enhances and facilitates nutrition/obesity-related clinical and translational research by assisting investigators in conducting studies in human subjects through the operation of two sub-cores. The Clinical Studies Performance sub-core facilitates clinical research by assistance with: i) subject recruitment, ii) planning and performance of clinical studies (i.e., a diverse array of tracer and non- tracer protocols such as the hyperinsulinemic-euglycemic clamp procedure, multi-tracer meal tests, intravenous and oral glucose tolerance tests, and arterial venous balance studies, to assess substrate and insulin kinetics), iii) body composition assessments [by using dual energy X-ray absorptiometry (DEXA), BodPod, Peapod, magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS)], iv) mixing of intravenous tracer and hormone solutions, v) acquisition of tissue (adipose, muscle, intestine) biopsy samples, vi) exercise (endurance and strength) and physical performance testing, vii) indirect calorimetry, viii) lifestyle (diet manipulation, behavioral therapy, exercise training, and weight loss/weight gain) interventions, ix) ingestive behavior (taste perception and preference) testing, and x) cardiovascular assessments (e.g., echocardiography, endothelial function, carotid artery intima-media thickness). The Metabolic Kinetics sub- core provides comprehensive services and training to study diverse areas of metabolic function, including: i) design of tracer and non-tracer protocols to evaluate in vivo substrate kinetics (e.g. glucose and fatty acid flux, VLDL-triglyceride secretion rate), insulin sensitivity, insulin secretion rates, and -cell function, ii) sample processing and measurement of stable isotope enrichment of metabolic substrates in blood, tissue, and primary human tissue culture samples, and iii) mathematical modeling of tracer and non-tracer data for the assessment of metabolic kinetics, insulin sensitivity, insulin secretion rates, and -cell function. In addition, the CSRC provides training for investigators, their staff, and research fellows in these areas of clinical research, both in the form of one-on-one hands-on instruction as well as through seminars and lecture series. Combining these services within one Core provides a cohesive organizational structure that facilitates the performance of complex clinical research studies, fosters interdisciplinary collaborations between NORC investigators, and reduces the barriers for basic scientists, and non-physician and young investigators who wish to conduct clinical research. The CSRC also ensures that all studies and procedures that are supported by the core are conducted in compliance with federal and local (state and hospital) regulations regarding research involving human subjects.

项目总结/摘要-临床科学研究核心： 临床科学研究核心（CSRC）加强和促进营养/肥胖相关的临床和 通过协助研究者在人类受试者中进行研究， 两个子核心。临床研究性能子核心通过以下方面的帮助促进临床研究：i） 受试者招募，ii）临床研究的计划和实施（即，各种各样的示踪剂和非- 示踪剂方案如高胰岛素-正常血糖钳夹程序，多示踪剂膳食试验， 静脉内和口服葡萄糖耐量试验以及动静脉平衡研究，以评估底物和 胰岛素动力学），iii）身体组成评估[通过使用双能X射线吸收测定法（DEXA）， BodPod、Peapod、磁共振成像（MRI）和磁共振波谱（MRS）]，iv） 静脉内示踪剂和激素溶液的混合，v）组织（脂肪、肌肉、肠）活检的获取 样品，vi）运动（耐力和力量）和物理性能测试，vii）间接量热法，viii） 生活方式（饮食控制、行为治疗、运动训练和体重减轻/体重增加）干预，ix） 摄食行为（味觉和偏好）测试，和x）心血管评估（例如， 超声心动图、内皮功能、颈动脉内膜中层厚度）。代谢动力学亚- 核心提供全面的服务和培训，以研究代谢功能的不同领域，包括：i） 设计示踪剂和非示踪剂方案以评价体内底物动力学（例如葡萄糖和脂肪酸流量， VLDL-甘油三酯分泌率）、胰岛素敏感性、胰岛素分泌率和细胞功能，ii）样品 处理和测量血液、组织中代谢底物的稳定同位素富集， 原代人组织培养样品，和iii）用于所述细胞的示踪剂和非示踪剂数据的数学建模， 评估代谢动力学、胰岛素敏感性、胰岛素分泌速率和细胞功能。此外该 中国证监会为研究者、其工作人员和研究人员提供这些临床研究领域的培训， 无论是在一对一动手指导的形式，以及通过研讨会和讲座系列。 将这些服务组合在一个核心中提供了一个有凝聚力的组织结构， 开展复杂的临床研究，促进NORC之间的跨学科合作 研究人员，并减少了基础科学家，非医生和年轻的研究人员， 希望进行临床研究。证监会还确保所有研究和程序， 根据联邦和地方（州和医院）法规进行 涉及人体的研究。