Hemodynamic analysis of parafoveal capillary in ischemic macropathy using adaptive optics scanning laser ophthalmoscopy

缺血性视网膜病变是糖尿病患者视力损害的主要原因之一。由于糖尿病视网膜病变（DR）和威胁视力的DR患者数量预计将在未来几年增加，因此需要进一步研究缺血性视网膜病变的治疗和评估技术。近年来，自适应光学扫描激光检眼镜（AO-SLO）实现了对光感受器和血流的无创、直接实时监测。我们用这种新方法来监测视网膜毛细血管中红细胞聚集物的流动。红细胞聚集体在正常受试者和DR患者的中央凹旁毛细血管中呈时间依赖性延长，且延长值在DR患者和正常人之间存在差异，表明DR患者的红细胞聚集体脆性较正常人低。监测暗尾的特征在评估视网膜血流动力学方面具有很大的潜力。

Ischemic retinopathy is one of the leading causes of visual impairment in diabetic patients. Since the number of patients with diabetic retinopathy (DR) and vision-threatening DR is expected to increase in coming years, further research on treatments and evaluation techniques for ischemic retinopathy is needed. Recently, Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO) has enabled noninvasive and direct monitoring of photoreceptors and blood flow in real time. We used this new method to monitor the flow of erythrocyte aggregates in the retinal capillary. Erythrocyte aggregates were elongated in a time-dependent manner in the parafoveal capillaries of normal subjects and DR patients and tis elongation values were different between DR patients and normal subjects, suggesting that erythrocyte aggregates in DR patients are less brittle than those in normal subjects. Monitoring the characteristics of dark tails has promising potential for evaluating retinal hemodynamics.