Cyclosporin A inhibits cell death of cornel endothelial cells by protecting mitochondrial membrane potential

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We corfirmed H2O2 induced a dose dependent increase in cell death of cultured human corneal endotehelial cells(HCECs). At concentration of 100nM, Cyclosporine A(CsA) attenuated the H2O2-induced cell death of HCECs by 15%.CsA significantly inhibited the permiability trasition pore(PTP) in H2O2 treaed HCECs. The mitochondrial membrane potential of H2O2 treated mouse corneal cup were protected by CsA at concetration of 100nM.Cyclosporine A protected mitochondrial menmbrane potential from oxidative stress, abd attenuated cell death of corneal endothelial cells.