Research for the molecular mechanism of Behcet's disease
Research for the molecular mechanism of Behcet's disease
批准号:
23791997
负责人:
KAWAGOE Tatsukata
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
白塞病新型转基因小鼠模型的研究进展和成果:白塞病的确切病因尚不清楚。然而,众所周知,人类白细胞抗原B51在白塞病患者中的发生率很高。在本研究中,我们建立了新的转基因小鼠来阐明人类白细胞抗原-B51在白塞病中的作用。
英文摘要
The progress and achievements of research on the new HLA-B51 transgenic mouse model of Behcet’s disease: The exact cause of Behcet’s disease is still unclear. However, it is well known that there is high incidence of HLA-B51 in patients with Behcet’s disease. In this study, we generated new transgenic mice to elucidate the function of HLA-B51 in Behcet’s disease.
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Targeted transgenesis through pronuclear injection of improved vectors into in vitro fertilized eggs
通过将改良载体原核注射到体外受精卵中进行靶向转基因
DOI:
10.1007/s11248-011-9505-y
发表时间:
2011
期刊:
Transgenic Research
影响因子:
3
作者:
[Ohtsuka, M., Miura, H., Nakaoka, H., Kimura, M., Sato, M., Inoko, H.]
通讯作者:
H.
DOI:
10.1016/j.humimm.2010.12.007
发表时间:
2011-03
期刊:
Human immunology
影响因子:
2.7
作者:
[Toshiro Sada;M. Ota;Y. Katsuyama;A. Meguro;E. Nomura;R. Uemoto;T. Nishide;E. Okada;S. Ohno;H. Inoko;N. Mizuki]
通讯作者:
Toshiro Sada;M. Ota;Y. Katsuyama;A. Meguro;E. Nomura;R. Uemoto;T. Nishide;E. Okada;S. Ohno;H. Inoko;N. Mizuki
ベーチェット病疾患関連遺伝子HLA-B51の機能解析
白塞氏病相关基因HLA-B51的功能分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N, 河越龍方]
通讯作者:
河越龍方
Development of a technique for efficient gene transfer to antral follicular cells in the mouse ovary
开发一种将基因有效转移至小鼠卵巢窦卵泡细胞的技术
DOI:
10.3109/19396368.2012.656796
发表时间:
2012
期刊:
Systems Biology in Reproductive Medicine
影响因子:
2.4
作者:
[Sato M, Akasaka E, Saitoh I, Ohtsuka M, Watanabe S]
通讯作者:
Watanabe S
DOI:
10.3109/09273948.2012.665124
发表时间:
2012-06-01
期刊:
OCULAR IMMUNOLOGY AND INFLAMMATION
影响因子:
3.3
作者:
[Takeuchi, Masaki, Asukata, Yuri, Mizuki, Nobuhisa]
通讯作者:
Mizuki, Nobuhisa
共 6 条
The search for HLA inhibitor using short ragweed allergy mouse model.
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批准号:25713058
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$5.41万
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财政年份:2013
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负责人:KAWAGOE Tatsukata
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依托单位: