Breakthrough of the pathogenesis and treatment strategy in necrotizing enterocolitis using two-photon laser scanning microscopy based on the alarmin concept.

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This research project is making the necrotizing enterocolitis model created in beta-actin-green fluorescent protein transgenic mice observed by two-photon laser-scanning microscopy(TPLSM) , and figuring out the pathogenesis and treatment of this disease using this model and system. As for the preliminary study, we performed the LPS induced septic model mouse, and achieved the observation of dynamic pathology of intestinal microcirculation in this septic model mouse. Nest stage, we tried to performed the necrotizing enterocolitis (NEC) model in neonatal mouse induced by LPS with hypoxia (with or without hypothermia exposure).