Remineralization of primary caries in dental enamel

牙釉质中原发龋的再矿化

基本信息

批准号：
23792182
负责人：
OGINO Reina
金额：
$ 2.75万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792182/
关键词：
エナメル質脱灰石灰化マイクロCT 漂白再石灰化ミネラル密度

项目摘要

This study aimed to examine the level of in vitro demineralization of human tooth enamel after bleaching using two common bleaching regimens: home-bleaching(HB), and office bleaching(OB). For the HB group, 10% carbamide peroxideHB gel was combined with artificial saliva. This mixture was applied to enamel for 2 h every day for 7 days. In between exposures, teeth were replaced in artificial saliva.For the OB group, teeth were exposed to 35% hydrogen peroxide OB agent and light curedthen maintained in artificial saliva before demineralization(OB+AS). We also included two control groups. The first was teeth that were completely untreated (Control). The secondcontrol was Light cured group (LC) that were not subjected to any bleaching but were light cured. The reduction in enamel density and the release of calcium into solution following storage of treated teeth in a demineralizing solution for 2 weeks was measured using fluorescence spectroscopy. We also visualized and quantified mineral d … More istribution in demineralized bleached enamel over time using a desktop micro-CT analyzer. HB or LC showed increased demineralization. In contrast, OB+AS was more resistant to demineralization. As mineral content and density decreases toward the dentin-enamel junction, whereas that of the enamel protein increases, this resistance todemineralization is presumably due to peroxide permeating to deeper layers of enamel before being activated by light curing, which enhances mineralization.OB+AS should be more highly mineralized and have higher resistance to acid attack. Consequently, OB＋AS were less demineralized than the other samples, even in the demineralizing solution, suggesting that the office bleaching regime exerts aprotective effect on tooth enamel. The present micro-CT evaluation revealed changes in the mineral distribution gradient in LC samples. This, concomitant with an increase in low density (i.e. less mineralized) enamel, can be permissive to severe enamel erosion in LC samples. Less

这项研究旨在使用两种常见的漂白方案（HB）和Office Bleaching（OB）检查在漂白后人类牙釉质的体外脱矿质水平。对于HB组，将10％的氨基甲酸酯过氧化物凝胶与人造唾液结合使用。将此混合物施加到搪瓷每天2小时，持续7天。在暴露之间，在人造唾液中取代了牙齿。对于OB组，牙齿暴露于35％过氧化氢OB剂中，并在脱矿物化之前在人工唾液中维持的光结晶（OB+AS）。我们还包括两个对照组。第一个是完全未经治疗的牙齿（对照）。第二个对照是轻质固化组（LC），未遭受任何漂白，但均经过光固化。使用荧光光谱测量了牙釉质密度的降低和将钙释放到脱矿质溶液中2周后的溶液。我们还使用桌面微型CT分析仪可视化和量化的矿物D…随着时间的流逝，债务底漆的更多剥夺。 HB或LC显示出债务否认的增加。相比之下，OB+对债务否定性更具抵抗力。随着矿物质含量和密度向牙本质 - 内胺交界处降低，而搪瓷蛋白的增加，这种对脱氧化的抵抗力大概是由于过氧化脱氧化含量在被矿物质固化之前激活更深的搪瓷层，从而增强了矿物质。因此，即使在债务解决方案中，OB+的债务较少，即使在债务解决方案中，这表明办公室漂白政权对牙齿搪瓷产生了影响。目前的Micro-CT评估揭示了LC样品中矿物分布梯度的变化。这与低密度（即矿化较少）牙釉质的增加相关，可以允许在LC样品中严重搪瓷侵蚀。较少的