Basic research about the clinical application as compression method new Ti/HA alloy implant material

本研究尝试通过施加压剪应力制备Ti-HA复合材料，并通过细胞培养实验研究成骨细胞在复合材料上的粘附增殖情况。随着HA含量的增加，MC 3 T3-E1细胞在复合材料上的粘附和增殖受到抑制。HA对细胞增殖的抑制作用不是由于其材料中释放的成分，而是材料的表面性质可能参与了这一机制。这些结果表明，HA本身可以抑制细胞生长，但由1100℃烧结热形成的HA部分化合物可以轻微地诱导细胞生长。细胞增殖的活性可能因磷灰石的性质而完全不同。

In the present study, there is a possibility that composites of Ti-HA were prepared by adding compressive shearing stress the adhesion proliferation of osteoblastic cells on the composites was investigated in culture cell experiments. The adhesionproliferation of MC3T3-E1 cultured cells on the composites was inversely suppressed by the increase in HA content. The inhibitory action of HA on the cell proliferation was not due to the released component from it materials, but rather the surface properties of the materials may beinvolved in this mechanism. These results suggest that the HA itself may inhibit the cell growth, but the compounds partially formed from HA by the 1100℃-sintering heat may induce cell growth slightly. The activity of cell proliferation may be entirely different by the nature of apatite.