Basic research about the clinical application as compression method new Ti/HA alloy implant material

压缩法新型Ti/HA合金植入材料临床应用基础研究

• 批准号: 23792292
• 负责人: ONUKI Hiroyuki
• 金额: $ 2.58万
• 依托单位: Meikai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792292/
• 关键词: ハイドロキシアパタイト; チタン; 複合材料; 骨芽細胞; Ti/Hap複合材料; 圧縮せん断法

In the present study, there is a possibility that composites of Ti-HA were prepared by adding compressive shearing stress the adhesion proliferation of osteoblastic cells on the composites was investigated in culture cell experiments. The adhesionproliferation of MC3T3-E1 cultured cells on the composites was inversely suppressed by the increase in HA content. The inhibitory action of HA on the cell proliferation was not due to the released component from it materials, but rather the surface properties of the materials may beinvolved in this mechanism. These results suggest that the HA itself may inhibit the cell growth, but the compounds partially formed from HA by the 1100℃-sintering heat may induce cell growth slightly. The activity of cell proliferation may be entirely different by the nature of apatite.

本研究采用加压切应力的方法制备了钛-羟基磷灰石复合材料，并通过细胞培养实验研究了成骨细胞在复合材料上的黏附增殖情况。随着HA含量的增加，MC3T3-E1培养细胞在复合材料上的黏附增殖受到相反的抑制。HA对细胞增殖的抑制作用不是由于材料释放的成分所致，而是材料的表面性质可能参与了这一机制。这些结果表明，HA本身可能会抑制细胞的生长，但HA经1100℃烧结后部分形成的化合物可能会轻微地促进细胞的生长。细胞增殖活性可能因磷灰石的性质而完全不同。