Influence on periodontal tissue with oxidized low-density lipoprotein

近年来，牙周炎与代谢综合征之间的关系已引起人们的关注，但其发生机制尚不清楚。我们发现，牙龈上皮细胞经oxLDL处理后，炎症细胞因子的产生明显增加，表明oxLDL参与了牙周病的进展。糖尿病组龈沟液中载脂蛋白B和氧化低密度脂蛋白水平显著高于非糖尿病组。GCF apoB和oxLDL与血浆中DM参数相关。

Recently, attention has been focused on the relation between periodontitis and metabolic syndrome; however, the mechanism responsible for this is yet to be clarified. We found that production of inflammatory cytokine by gingival epithelial cells was significantly increased when the cells were treated with oxLDL.It showed that oxLDL participated in progression of periodontal disease. Moreover, apoB and oxLDL in gingival crevicular fluid (GCF) were significantly higher in the DM patients than in the non-DM subjects. GCF apoB and oxLDL correlates with DM parameters in plasma.