Catalytic Asymmetric Synthesis of Chiral Fluorinated Molecules

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Introduction of a trifluoromethyl group into biologically active compounds often modifies their physical and/or biological properties. Here, we have succeeded in the enantioselective Diels-Alder reaction of β-trifluoromethylacrylates to give corresponding cyclohexenes having a trifluoromethyl group at the chiral carbon center. We also demonstrated the organocatalytic asymmetric 1,4-addition of 4,4,4-trifluorocrotonaldehyde.The resulting adducts could be converted into potential synthetic intermediates for new drug candidates.