Development of porphyrin photosensitizer for photodynamic therapy

点击翻译按钮获取中文摘要

The purpose of this study is the development of novel photosensitizer for photodynamic therapy (PDT), which is a less invasive treatment of cancer. In general, porphyins were used as the PDT photosensitizer. Administered porphyrins can generate singlet oxygen to photosensitize biomolecules oxidation. However, since the oxygen concentration is relatively low in tumor, the PDT effect in tumor is restricted. In this study, P(V)porphyrins were used as photosensitizers. P(V)porphyrins induced the oxidation of amino acid residue in a water soluble protein, a target model biomolecule, during visible-light irradiation. It was confirmed that the mechanism of protein photodamage by these porphyrins is singlet oxygen generation and photo-induced electron transfer. For this experiment, the novel analysis method to detect the protein damage was developed. Further, the novel porphyrin photosensitizers were synthesized and their activities were demonstrated.