Development of novel fiber-based light sources for coherent Raman scattering imaging

本研究的重点是开发用于相干拉曼散射显微镜快速稳定光谱成像的新型光纤光源。利用高度非线性光纤，将其零色散波长调谐到近红外波长，研制了光参量振荡器和稳定的超连续光源。在确定了光源的基础上，研制了相干反斯托克斯拉曼散射（CARS）显微镜和近场CARS显微镜。在不改变泵浦和Stokes脉冲之间的群延迟的情况下，测量了指纹区域DNA组成分子的CARS光谱，显著缩短了数据采集时间。此外，还实现了隔离的单壁碳纳米管的高分辨率CARS成像，其空间分辨率为60 nm，光谱分辨率为30 cm^<-1>。这些结果发表在科学文献上。

This research focused on the development of novel fiber sources for rapid and stable spectral imaging in a coherent Raman scattering microscope. An optical parametric oscillator as well as a stable supercontinuum source were developed using a highly nonlinear optical fibers with their zero dispersion wavelengths tuned to near-infrared wavelengths. Having established the light sources, a coherent anti-Stokes Raman scattering (CARS) microscope and a near-field CARS microscope were developed. CARS spectra of DNA constituent molecules in the finger-print region were measured without modifying the group delay between the pump and the Stokes pulses, significantly decreasing the data acquisition time. Moreover, high resolution CARS imaging was realized for an isolated single-walled carbon nanotube with spatial resolution of 60 nm and spectral resolution of 30 cm^<-1>. These results were published in a scientific literature.