Identification of marine biocompound producers within sponges using the single-cell approach and their in vitro cultivation

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Marine sponges are considered as the largest producers of highly significant natural compounds. In this research, the goal was to apply the single cell analytical approach to identify the real producers of such important compounds. Targeting the compound Onnamide A, the research was successful in identifying the true producer and reported the first identification of a natural compound producer from uncultivated bacteria. Further genomic analysis also revealed that this bacterium harbored numerous biosynthetic pathways, similar to that of its cultivable counterparts such as Pseudomonas, Bacillus and actinomycetes.