The role of host factors in LINE retrotransposition

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Transposable elements, including LINEs, are major components of eukaryotic genomes. They mobilize and amplify their own copies via the reverse transcription of their own RNA. This mobilization mechanism is called retrotransposition, and it requires proteins encoded by transposable elements. However, retrotransposition is not completed by the proteins only, and host encoded proteins are most likely required for retrotransposition. This study found that a retrotransposition intermediate of LINEs contains a large amount of host encoded proteins, which probably participate in retrotransposition.