Elucidation of mechanisms of plant innate immunity by R protein

R蛋白Pit是感受稻瘟病菌的胞内受体。在本项目中，我们发现Pit通过GDP/GTP交换因子OsSPIKE1激活小GTP酶Osrac1。通过OsSPIKE1激活Pit依赖的Osrac1在Pit介导的抗病中起着重要作用。Pit的棕榈酰化在质膜上的小GTP酶Osrac1的激活中起着关键作用。此外，我们还确定了Pit的新的相互作用因子。

R protein Pit acts as an intracellular receptors for sensing the blast fungus. In this project, we found that Pit activates small GTPase OsRac1 through a GDP/GTP exchange factor OsSPIKE1. Pit-dependent OsRac1 activation via OsSPIKE1 playsimportant role in Pit-mediated disease resistance. Palmitoylation of Pit plays a critical role in activation of small GTPase OsRac1 on the plasma membrane. In addition, we identified the novel interactors of Pit.