Novel Role of mitotic cell rounding in epithelial invagination

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Animal cells change their shape into sphere upon mitotic entry. In this study, we revealed a novel active role of mitotic cell rounding in epithelial invagination of the Drosophila tracheal placode. Mitotic rounding, but not cell division, of the central cells in the placode is required to accelerate invagination, in conjunction with centripetal pressure from the surrounding cells. These results indicate that mitotic rounding regulates the epithelial tissue morphogenesis independent of its role in cell division.