Research for a mechanism for generation of GnRH pulse regulated by neural activity of kisspeptin neurons in the arcuate nucleus

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Kisspeptin neurons in the arcuate nucleus (ARC) might regulate pulsatile secretion of GnRH/LH. Neural activity of the majority of these neurons might burst simultaneously, however a mechanism for this phenomenon still remains unclear. In this study, we addressed how mechanism controls the simultaneous burst of majority of the ARC kisspeptin neurons. The ARC kisspeptin neurons have neural network each other by their fibers in the contralateral as well as ipsilateral side. And recording of neural activity revealed that neural activity of ARC kisspeptin neurons from both side were synchronized. These results suggest that synchronized neural activity of majority of ARC kisspeptin neurons might be controlled by neural network using their fibers.