Breaking immunological tolerance to canine malignant melanoma using anti-Gpnmb antibody and various antigen peptides associated with tumor.

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We investigated new approachof immunological therapy for canine malignant melanoma, using anti-Gpnmb Ab and other various antigen peptides associated with tumor. The research showed that some peptides significantly activated T-lymphocytes compared to conventional method. However, the experiments with anti-Gpnmb Ab did not show notable results in T-cell activation. In the future research, we will thoroughly examine experimental conditions and intend to find more effective immunotherapy.