Analysis of polyamine regulation systems in plants and exploration of functional molecules based on polyamine structure

植物多胺调控系统分析及基于多胺结构的功能分子探索

• 批准号: 23780345
• 负责人: TAKAHASHI Yoshihiro
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23780345/
• 关键词: 代謝工学; ポリアミン; ポリアミンオキシターゼ; イネ; 病原菌抵抗性反応; シロイヌナズナ

Polyamines are important not only for developmental processes but also for various environmental stress responses in plants. In order to elucidate the regulatory system responsible for polyamine homeostasis and action, I focused on polyamine degradationenzyme, polyamine oxidase (PAO), and identified three different genes coding for main PAOs in rice. These proteins were localized to peroxisomes and catalyzed polyamine back conversion. Moreover, it was found that one of the common tetraamines, thermospermine, is involved in disease resistance as a signal molecule like spermine.

多胺不仅对发育过程，而且对于植物的各种环境压力反应都很重要。为了阐明负责多胺稳态和动作的调节系统，我专注于多胺降解酶，多胺氧化酶（PAO），并确定了编码大米中主要PAO的三个不同基因。这些蛋白质定位于过氧化物酶体和催化的多胺背部转化。此外，发现其中一种普通的四胺热植物与疾病抗性有关，作为像精子这样的信号分子。

项目成果

Constitutively and highly expressed Oryza sativa polyamine oxidases localize in peroxisomes and catalyze polyamine back conversion

• DOI: 10.1007/s00726-011-1002-3
• 发表时间: 2012-02
• 期刊: Amino Acids
• 影响因子: 3.5
• 作者: Y. Ono;D. W. Kim;Kanako Watanabe;A. Sasaki;M. Niitsu;T. Berberich;T. Kusano;Yoshihiro Takahashi-Yoshihiro-Ta