Novel synthesis of biaryls via metal-free cross-coupling reaction and its application

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Biaryl compounds are versatile building blocks in the synthesis of natural products, pharmaceuticals, agricultural chemicals and π-conjugated organic materials. Therefore, the development of convenient cross-coupling reaction for giving biaryls is one of the important subjects in organic chemistry.Recently, we have developed a new synthetic method that enables metal-free regioselective oxidative coupling of 3-substituted thiphenes using hypervalent iodine(III) reagents. I have applied our coupling reaction of thiphenes to the synthesis of thiophene organic dyes as MK-2. Futher study for the oxidative coupling reaction, we also developed a metal-free direct synthesis of the discotic liquid crystal hexahydroxytriphenylene (HHTP) using hypervalent iodine reagent.