Analysis of Microsomal prostaglandin E synthase-1 (mPGES-1) in the facial nerve regeneration.

微粒体前列腺素 E 合酶-1 (mPGES-1) 在面神经再生中的分析。

• 批准号: 23790099
• 负责人: KAMEI Daisuke
• 金额: $ 2.75万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790099/
• 关键词: 脂質; 薬理学; プロスタグランジン; 顔面神経麻痺; 末梢神経; mPGES-1; PGE2

An effective therapy is not established for aggravation of the peripheral facial nerve palsy. Microsomal prostaglandin E synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase in the prostaglandin E2 (PGE2)-biosynthetic pathway. In this study, we examined the in vivo role of mPGES-1 in the facial nerve regeneration using a mouse model of facial nerve crush injury. In vivo studies showed that contribution of PGE2 and mPGES-1 was found in the process of regeneration of facial nerve after crush injury. This study suggested that inhibition of PGE2 was useful as a new therapy for peripheral facial nerve palsy.

对于周围性面神经麻痹的加重，尚未建立有效的治疗方法。微粒体前列腺素E合酶-1（mPGES-1）是一种刺激诱导型酶，在前列腺素E2（PGE 2）生物合成途径中的环氧合酶下游发挥作用。在这项研究中，我们研究了mPGES-1在面神经再生中的作用，使用小鼠模型的面神经挤压伤。在体研究表明，PGE 2和mPGES-1参与了面神经挤压伤后的再生过程。提示抑制PGE 2可能成为治疗周围性面神经麻痹的一种新方法。

项目成果

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

• DOI: 10.1002/jnr.23217
• 发表时间: 2013-07-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Akitake, Yoshiharu;Nakatani, Yoshihito;Takahashi, Mitsuo
• 通讯作者: Takahashi, Mitsuo

マウス末梢性顔面神経麻痺モデルの樹立と解析

小鼠周围性面神经麻痹模型的建立及分析

• 发表时间: 2012
• 作者: 竹本伊織;亀井大輔;佐久間莉乃;丸山梨詠;江崎伸一;村上信吾;増田豊
• 通讯作者: 増田豊

過敏性腸症候群の治療抵抗性因子に関する検討

肠易激综合征治疗抵抗因素研究

• 发表时间: 2012
• 作者: 秋山加菜;亀井大輔;福本滋;竹内義明;米山啓一郎;増田豊
• 通讯作者: 増田豊

Physiological Roles of Group X-secreted Phospholipase A2 in Reproduction, Gastrointestinal Phospholipid Digestion, and Neuronal Function*

• DOI: 10.1074/jbc.m110.206755
• 发表时间: 2011-01
• 期刊: The Journal of Biological Chemistry
• 作者: Hiroyasu Sato;Y. Isogai;Seiko Masuda;Y. Taketomi;Y. Miki;D. Kamei;S. Hara;Tetsuyuki Kobayashi;Y. Ishikawa;T. Ishii;K. Ikeda;R. Taguchi;Y. Ishimoto;N. Suzuki;Y. Yokota;K. Hanasaki;Toshiko Suzuki-Yamamoto;Kei Yamamoto;M. Murakami

Advanced curriculum for clinical assessment and skill in new age pharmacist education

新时代药师教育临床评估与技能高级课程

• 发表时间: 2013
• 期刊: Yakugaku Zasshi
• 影响因子: 0.3
• 作者: Kiuchi Y;Masuda Y;Kamei D;Kogo M;Nakamura A.
• 通讯作者: Nakamura A.