Analysis of Microsomal prostaglandin E synthase-1 (mPGES-1) in the facial nerve regeneration.

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An effective therapy is not established for aggravation of the peripheral facial nerve palsy. Microsomal prostaglandin E synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase in the prostaglandin E2 (PGE2)-biosynthetic pathway. In this study, we examined the in vivo role of mPGES-1 in the facial nerve regeneration using a mouse model of facial nerve crush injury. In vivo studies showed that contribution of PGE2 and mPGES-1 was found in the process of regeneration of facial nerve after crush injury. This study suggested that inhibition of PGE2 was useful as a new therapy for peripheral facial nerve palsy.