Analysis of microsomal prostaglandin E synthase (mPGES-1) in chemical carcinogen-induced colon carcinogenesis

本研究旨在探讨微粒体前列腺素E合成酶-1（mPGES-1）作为前列腺素E_2（PGE_2）的最后一个合成酶作为肿瘤治疗新靶点的可能性。在本研究中，我们使用各种mPGES-1基因修饰小鼠，分析了氧化偶氮甲烷诱导的结肠肿瘤发生模型。结果发现，mPGES-1作为恶化因素有助于结直肠癌的发生、促进和进展。这项研究表明，抑制mPGES-1可能有助于新作用机制的抗癌治疗。

We aimed at the possibility of microsomal prostaglandin E synthase-1 (mPGES-1), which was last synthase of PGE_2, as new therapeutic target of cancer. In this study, using various mPGES-1 gene modification mice, we analyzed the azoxymethane-induced colon tumorigenesis model. As a result, it was found that mPGES-1 contributed to initiation, promotion and progression of colorectal cancer as an exacerbation factor. This study suggested the possibility that inhibition of mPGES-1 was useful as an anticancer therapy of new mechanism of action.