Investigation of relationship between the pharmacokinetics of and clinical responses to prochlorperazine in patients receiving opioids

接受阿片类药物治疗的患者中丙氯拉嗪的药代动力学与临床反应之间关系的研究

• 批准号: 23790181
• 负责人: NAITO Takafumi
• 金额: $ 2.75万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790181/
• 关键词: プロクロルペラジン; オピオイド; 薬物動態; 有害作用; ドパミンD2受容体; オピオイドμ1受容体; 遺伝子多型; 緩和医療; オキシコドン; オピオイド誘発性嘔吐; プロラクチン; がん性疼痛; 制吐薬; 代謝物; TDM

Prochlorperazine has a high potency antiemetic effect based on inhibiting dopamine D2 receptor and is commonly used for the treatment of opioid-induced nausea and vomiting in cancer patients. Clinical responses to prochlorperazine vary in patients receiving opioids. Opioids bind to opioid receptor mu1 on the hypothalamus and subsequently cause the blockade of dopaminergic pathways. This study evaluated the interindividual variation in pharmacokinetics of and clinical responses to prochlorperazine based on non-genetic and genetic factors in patients receiving opioids.

丙氯拉嗪具有基于抑制多巴胺D2受体的高效止吐作用，通常用于治疗癌症患者中阿片类药物诱导的恶心和呕吐。接受阿片类药物治疗的患者对丙氯拉嗪的临床反应各不相同。阿片类药物与下丘脑上的阿片受体μ 1结合，随后引起多巴胺能通路的阻断。本研究基于接受阿片类药物治疗的患者的非遗传和遗传因素，评价了丙氯拉嗪药代动力学和临床反应的个体间差异。

项目成果

Relationships between prochlorperazine pharmacokinetics and Its clinical responses based on DRD2 gene polymorphisms in cancer patients receiving opioid analgesics

基于DRD2基因多态性的癌症患者接受阿片类镇痛药的丙氯拉嗪药代动力学与其临床反应的关系

• 发表时间: 2011
• 作者: Tashiro M;Naito T;Takashina Y;Kagawa Y;Kawakami J
• 通讯作者: Kawakami J

Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients.

遗传和非遗传因素对羟考酮治疗的癌症患者对丙氯拉嗪临床反应的影响。

• DOI: 10.1016/j.cca.2013.12.011
• 发表时间: 2014
• 期刊: Clin Chim Acta.
• 作者: Tashiro M;Naito T;Ohnishi K;Kagawa Y;Kawakami J.
• 通讯作者: Kawakami J.

Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry

等度液相色谱串联质谱法同时测定人血浆中丙氯拉嗪及其代谢物

• DOI: 10.1002/bmc.1725
• 发表时间: 2012
• 期刊: Biomed Chromatogr
• 影响因子: 1.8
• 作者: Tashiro M;Naito T;Kagawa Y;Kawakami J
• 通讯作者: Kawakami J

がん患者におけるプロクロルペラジンの制吐作用および有害作用に及ぼすDRD2の遺伝子変異の影響

DRD2基因突变对癌症患者止吐及丙氯拉嗪不良反应的影响

• 发表时间: 2011
• 作者: Hisamitsu Hayashi;Kaori Inamura;Kensuke Aida;Sotaro Naoi;Asami Hattori;Takashi Yabuki;Yuichi Sugiyama;田代将貴,内藤隆文,賀川義之,川上純一
• 通讯作者: 田代将貴,内藤隆文,賀川義之,川上純一