Alteration of renal drug transporters during growth and its effects on the pharmacokinetics

生长过程中肾脏药物转运蛋白的变化及其对药代动力学的影响

• 批准号: 23790182
• 负责人: MOTOHASHI Hideyuki
• 金额: $ 2.75万
• 依托单位: Kyoto Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790182/
• 关键词: 薬学; 医療系薬学; トランスポータ; 腎臓; 薬物腎排泄; 小児; 薬物動態

The purpose of this study was to elucidate the developmental changes in the expression of transporters and their effects on the renal excretion of drugs. The protein expression of the transporters were very low at postnatal day 0 and gradually increased with age. On the other hand, the tubular secretion of PSP was significantly lower in postnatal day 14 rats than adult rats. These results indicate that age-dependent changes in organic anion transporter expression affect the tubular secretion of anionic drugs in pediatric patients.

本研究的目的是阐明转运蛋白表达的发育变化及其对肾脏药物排泄的影响。这些转运蛋白的表达在出生后第0天非常低，随着年龄的增长逐渐增加。另一方面，出生后第14天大鼠的小管分泌量明显低于成年大鼠。这些结果表明，有机阴离子转运蛋白表达的年龄依赖性变化影响儿科患者小管阴离子药物的分泌。

项目成果

Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein

大鼠肾脏肾有机阴离子转运蛋白的发育表达及其对肾分泌酚磺酞的影响

• 发表时间: 2012
• 期刊: Am J Physiol Renal Physiol
• 作者: Nomura M;Motohashi H;Sekine H;Katsura T;Inui K
• 通讯作者: Inui K

Effects of Metabolic Acidosis on Expression Levels of Renal Drug Transporters

• DOI: 10.1007/s11095-010-0348-7
• 发表时间: 2011-05-01
• 期刊: PHARMACEUTICAL RESEARCH
• 影响因子: 3.7
• 作者: Gaowa, Arong;Motohashi, Hideyuki;Inui, Ken-ichi
• 通讯作者: Inui, Ken-ichi

Annual Review腎臓2013Clinical nephrology尿細管・間質障害副作用発現における腎薬物トランスポータの寄与

2013年肾脏年度回顾临床肾病学肾药物转运蛋白对肾小管和间质疾病副作用发展的贡献

• 发表时间: 2013
• 作者: Enoche F.Oga;関根秀一;設楽悦久;堀江利治;本橋秀之
• 通讯作者: 本橋秀之

Developmental expression of renal organic anion transporters and its effect on the renal drug secretion

肾脏有机阴离子转运蛋白的发育表达及其对肾脏药物分泌的影响

• 发表时间: 2011
• 作者: 張正宇;内田康雄;立川正憲;寺崎哲也;Nomura M
• 通讯作者: Nomura M

Effect of Metabolic Acidosis on Urinary Drug Excretion

代谢性酸中毒对尿药物排泄的影响

• 发表时间: 2011
• 作者: 張正宇;内田康雄;立川正憲;寺崎哲也;Nomura M;Gaowa A
• 通讯作者: Gaowa A