Research on the physiological roles of TRP channels in astrocyte activation induced by a lipid mediator

鞘氨醇-1-磷酸(S1P)是一种具有生物活性的脂质，在调节多种细胞的生长、存活和迁移方面发挥着重要作用，但其在脑中的作用尚不清楚。瞬时受体电位通道(TRPC)是一种钙离子通透性非选择性阳离子通道，在星形胶质细胞中表达，参与G偶联受体刺激后的钙离子内流。在本研究中，我们证明了S1P诱导的钙反应和由此产生的CXCL1的释放可以归因于TRPC介导的细胞外钙离子进入培养的星形胶质细胞。S1P诱导的星形胶质细胞激活机制尚需进一步研究

Sphingosine-1-phosphate (S1P) is a biologically active lipid that has an important role in regulating the growth, survival and migration of a variety of cells; however their roles in the brain remain to be elucidated. Transient Receptor Potential Canonical (TRPC) channels, Ca^<2+>-permeable nonselective cation channels, are expressed in astrocytes and involved in Ca^<2+>influx after G-coupled receptor stimulation. In the present study, we demonstrate that S1P-induced Ca^<2+>responses and resultant CXCL1 release can be attributed to TRPC-mediated extracellular Ca^<2+>entry in culturedastrocytes. Further investigations are required to identify the mechanisms of S1P-evoked astrocyte activation