Research on the physiological roles of TRP channels in astrocyte activation induced by a lipid mediator

1-磷酸鞘氨醇（S1 P）是一种生物活性脂质，在调节多种细胞的生长、生存和迁移方面具有重要作用;但它们在大脑中的作用仍有待阐明。瞬时受体电位经典（TRPC）通道是一种Ca^2+可渗透的非选择性阳离子通道，在星形胶质细胞中表达，并参与G偶联受体刺激后的Ca^2+内流。在本研究中，我们证明了S1 P诱导的Ca^<2+>反应和由此产生的CXCL 1释放可归因于TRPC介导的培养星形胶质细胞细胞外Ca^<2+>内流。需要进一步的研究来确定S1 P诱发的星形胶质细胞激活的机制

Sphingosine-1-phosphate (S1P) is a biologically active lipid that has an important role in regulating the growth, survival and migration of a variety of cells; however their roles in the brain remain to be elucidated. Transient Receptor Potential Canonical (TRPC) channels, Ca^<2+>-permeable nonselective cation channels, are expressed in astrocytes and involved in Ca^<2+>influx after G-coupled receptor stimulation. In the present study, we demonstrate that S1P-induced Ca^<2+>responses and resultant CXCL1 release can be attributed to TRPC-mediated extracellular Ca^<2+>entry in culturedastrocytes. Further investigations are required to identify the mechanisms of S1P-evoked astrocyte activation