Research on the new pathophysiological roles of TRPV channel that could regulate the activation of brain cells

小胶质细胞是大脑中的内在免疫细胞。在神经退行性疾病的反应中，过度活化的小胶质细胞改变其形状并释放参与CNS疾病发病机制的各种细胞因子。本研究主要研究TRPV4通道在小胶质细胞中的表达。体内外实验表明，TRPV 4通道开放引起的去极化可减弱细胞外Ca2+的驱动力，抑制小胶质细胞的活化。

Microglia are intrinsic immune cells in the brain. In response to neurodegenerative diseases, excessively activated microglia change their shapes and release various cytokines involved in the pathogenesis of CNS disease. This study focused on TRPV4 channel expressed in microglia. In vitro and in vivo experiments demonstrate that the depolarization in response to the opening of TRPV4 channel attenuates the driving force for extracellular Ca2+ and suppresses microglial activation.