Search for disease-specific factors on the pathological specimens using the phage display method.

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Phage display technology is a powerful method for the selection of monoclonal antibodies against a given antigen. In the present study, we created disease-specific antibody by using a material marrow myelodysplastic syndrome (MDS) patients to "anti-disease specific antibody". Results of the study, it was possible to obtain about 3000 phage antibody clones capable of binding only to MDS bone marrow specimens. By using the polyclonal by mixing the clones obtained, it was possible to build immunostaining dyed only MDS samples poor prognosis. In the future, we will carry outthe identification of disease-causing factor.