Investigation into the relationship between prognosis and characteristics of macrophages in malignant lymphomas

恶性淋巴瘤预后与巨噬细胞特征关系的探讨

• 批准号: 23790398
• 负责人: WADA Naoki
• 金额: $ 2.5万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790398/
• 关键词: 血液; 悪性リンパ腫

Immunohistochemical double staining with antibodies for HLA-DR/CD68 (markers for M1-tumour-associated macrophage [M1-TAM]) or CD163/CD68 (M2-TAM) was performed to investigate the significance of TAMs in diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In DLBCL, a higher number of M2-TAM was a significant factor for poor prognosis. The overall survival rate of the patients with DLBCL-IF, DLBCL showing an interfollicular pattern of proliferation preserving lymphoid follicles, was significantly better than those withDLBCL control group. All DLBCL-IF patients with a low M2-TAM count were alive at the end of observation. In HL, a higher number of M2-TAM was significantly correlated with shorter overall survival. When confined to mixed cellularity subtype of HL, a higher number of M1-TAM was significantly correlated with favorable prognosis.

应用免疫组化双标法检测弥漫性大B细胞淋巴瘤（DLBCL）和霍奇金淋巴瘤（HL）中肿瘤相关巨噬细胞标志物HLA-DR/CD 68（M1-TAM）或CD 163/CD 68（M2-TAM）。在DLBCL中，较高数量的M2-TAM是预后不良的重要因素。DLBCL-IF患者的总生存率明显高于DLBCL对照组，DLBCL表现为滤泡间型增殖保留淋巴滤泡。所有M2-TAM计数低的DLBCL-IF患者在观察结束时均存活。在HL中，较高数量的M2-TAM与较短的总生存期显著相关。当局限于HL的混合细胞亚型时，较高数量的M1-TAM与良好的预后显著相关。

项目成果

Tumor-associated macrophages (TAMs) in diffuse large B-cell lymphoma (DLBCL)

弥漫性大 B 细胞淋巴瘤 (DLBCL) 中的肿瘤相关巨噬细胞 (TAM)

• 发表时间: 2012
• 作者: Toshifumi Yokoyama;Sung-Min Kim;Ferhat Ulu;and Yukiko Yamazaki;和田直樹 (発表代表者)
• 通讯作者: 和田直樹 (発表代表者)

Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma

• DOI: 10.1007/s00428-011-1140-8
• 发表时间: 2011-10-01
• 期刊: VIRCHOWS ARCHIV
• 影响因子: 3.5
• 作者: Zaki, Mona A. A.;Wada, Naoki;Aozasa, Katsuyuki
• 通讯作者: Aozasa, Katsuyuki

Tumour-associated macrophages in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group

• DOI: 10.1111/j.1365-2559.2011.04096.x
• 发表时间: 2012-01-01
• 期刊: HISTOPATHOLOGY
• 影响因子: 6.4
• 作者: Wada, Naoki;Zaki, Mona A. A.;Aozasa, Katsuyuki
• 通讯作者: Aozasa, Katsuyuki