Investigation into the relationship between prognosis and characteristics of macrophages in malignant lymphomas

应用免疫组化双标法检测弥漫性大B细胞淋巴瘤（DLBCL）和霍奇金淋巴瘤（HL）中肿瘤相关巨噬细胞标志物HLA-DR/CD 68（M1-TAM）或CD 163/CD 68（M2-TAM）。在DLBCL中，较高数量的M2-TAM是预后不良的重要因素。DLBCL-IF患者的总生存率明显高于DLBCL对照组，DLBCL表现为滤泡间型增殖保留淋巴滤泡。所有M2-TAM计数低的DLBCL-IF患者在观察结束时均存活。在HL中，较高数量的M2-TAM与较短的总生存期显著相关。当局限于HL的混合细胞亚型时，较高数量的M1-TAM与良好的预后显著相关。

Immunohistochemical double staining with antibodies for HLA-DR/CD68 (markers for M1-tumour-associated macrophage [M1-TAM]) or CD163/CD68 (M2-TAM) was performed to investigate the significance of TAMs in diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In DLBCL, a higher number of M2-TAM was a significant factor for poor prognosis. The overall survival rate of the patients with DLBCL-IF, DLBCL showing an interfollicular pattern of proliferation preserving lymphoid follicles, was significantly better than those withDLBCL control group. All DLBCL-IF patients with a low M2-TAM count were alive at the end of observation. In HL, a higher number of M2-TAM was significantly correlated with shorter overall survival. When confined to mixed cellularity subtype of HL, a higher number of M1-TAM was significantly correlated with favorable prognosis.