Spatiotemporal spread of inflammation caused by HMGB1 nuclear DNA-binding protein

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High-mobility group box-1 protein (HMGB1) was originally described as a nuclear DNA-binding protein that facilitates gene transcription by stabilizing nucleosome formation. HMGB1 can also be released or secrete extracellularly from cells as a result of cellular necrosis or activated macrophages/monocytes in response to inflammatory stimuli respectively, and acts as a pro-inflammatory cytokine or alarm signal for tissue damage. We have revealed that HMGB1 can trigger a potent inflammatory response and accelerates granulomatous inflammation leading to severe tissue injury. In this study, we tried to disclose further mechanism of HMGB1- associated granulomatous inflammation. From a point of view that controlling HMGB1 is essential for treatment of granulomatous nephritis, we studied experiments using a granulomatous nephritis animal model to investigate follows;1． The relationship between degrees of the nephritis and HMGB1 receptors expression2． The effect of anti-HMGB1 antibody3． TM association of the nephritis4． Reactive oxygen species association of the nephritisWe have found that receptors of HMGB1 and TM could be a target for inhibiting granulomatous nephritis.