Elucidation of hematopoietic disturbance in malaria

在这项研究中，通过对感染了疟原虫的γ δ T细胞缺陷小鼠（TCR-delta KO小鼠）的分析，我们认为γ δ T细胞可能参与了伯氏疟原虫XAT感染后的脾造血。另一方面，在感染寄生虫后，我们观察到TCR-delta KO小鼠外周血中造血细胞的比例高于WT小鼠。这一结果表明，γ δ T细胞可能参与了寄生虫感染后造血细胞归巢到脾脏的过程。然而，为了阐明疟疾中伽马δ T细胞相关造血的机制。此外，在本研究的过程中，我们阐明了CD40配体和产生ifn - γ的γ δ T细胞增强树突状细胞的激活，从而产生对伯氏疟原虫XAT的保护性免疫。

In this study, by analyses using gamma delta T cell-deficient mice (TCR-delta KO mice) with plasmodium infection, we suggest that gamma delta T cell would be involve in splenic hematopoiesis after infection with Plasmodium berghei XAT. On the other hands, after infection with the parasites, we observed higher proportion of hematopoietic cells in peripheral blood of TCR-delta KO mice than that of WT mice. This result suggests that gamma delta T cells would be involved in homing of hematopoietic cells to spleen after infection with the parasites. However, to elucidate of the mechanisms for gamma delta T cell-related hematopoiesis in malaria. Furthermore, in the process of this study, we elucidated that CD40 Ligand and IFN-gamma-producing gamma delta T cells enhance dendritic cell activation, resulting in protective immunity against Plasmodium berghei XAT.