Type-I IFNs regulate the protective response against pneumococcal infection in splenic marginal zone.

I 型干扰素调节脾边缘区针对肺炎球菌感染的保护性反应。

• 批准号: 23790487
• 负责人: UCHIYAMA Ryosuke
• 金额: $ 2.83万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790487/
• 关键词: 感染免疫; 肺炎球菌; I型インターフェロン; 辺縁帯B細胞; 莢膜

Streptococcus pneumoniae is a causative agent of bacterial pneumonia in human. The bacterial cell wall components contain the capsular polysaccharides which play an important role for evading the host immune responses. That is why the antibody specific for capsular polysaccharides is protective against S. pneumoniae infection by inducing the activation of complements system and phagocytosis by macrophages or dendritic cells. Type-I interferons (IFNs) were shown to be induced in response to S. pneumoniae infection, and possibly regulate the bacterial infection. However, it is not clear whether the type-I IFNs affect the antibody production against pneumococcalcapsular polysaccharides from splenic marginal zone B cells. This study revealed the effects of Type-I IFNs against marginal zone B cells for production of IgM specific for pneumococcal capsular polysaccharides

肺炎链球菌是人类细菌性肺炎的病原体。细菌细胞壁成分含有荚膜多糖，在逃避宿主免疫反应方面发挥着重要作用。这就是为什么荚膜多糖特异性抗体通过诱导补体系统的激活和巨噬细胞或树突状细胞的吞噬作用来防止肺炎链球菌感染。 I 型干扰素 (IFN) 被证明是响应肺炎链球菌感染而被诱导的，并且可能调节细菌感染。然而，尚不清楚I型干扰素是否影响脾边缘区B细胞针对肺炎球菌荚膜多糖的抗体产生。这项研究揭示了 I 型干扰素对边缘区 B 细胞产生肺炎球菌荚膜多糖特异性 IgM 的影响

项目成果

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Protective effect of polysaccharide vaccine in splenectomized mice against infection of Streptococcus pneumoniae

多糖疫苗对脾切除小鼠肺炎链球菌感染的保护作用

• 发表时间: 2011
• 作者: Uchiyama Ryosuke;Tsutsui Hiroko
• 通讯作者: Tsutsui Hiroko