Producing mechanism and function of IFN-λin nasal epithelial cells infected with RS-virus.

RS病毒感染鼻上皮细胞产生IFN-λ的机制及功能。

• 批准号: 23790507
• 负责人: OKABAYASHI Tamaki
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790507/
• 关键词: RS ウイルス; hTERT 導入ヒト正常細胞; 自然免疫; RSウイルス; ｈTERT導入ヒト正常鼻細胞; ｈＴＥＲＴ導入ヒト正常鼻粘膜上皮細胞; IFN-lambda

We reported that IFN-λ is the predominant IFN induced from RSV infected nasal epithelial cells. However, there were no-significant difference between IFN-λand IFN-βin nasal discharge of RSV-infected child. Streptococcus pneumonia and chemokines in nasal discharge were detected. Humuleone, the main constituent of hop bitter acids, inhibited RSV replication and chemokines production, and Clarithromycis, antimicrobial agent, inhibited chemokines production and PAF expressioni, which is the receptor of S. pneumonia. These results suggested new treatment approach to RSV infection.

我们报道了IFN-λ是RSV感染鼻上皮细胞诱导的主要IFN。但RSV感染儿童鼻分泌物中IFN-λ和IFN-β的含量差异无统计学意义。检测鼻分泌物中肺炎链球菌和趋化因子。蛇麻酮是啤酒花苦味酸的主要成分，它能抑制RSV的复制和趋化因子的产生，而克拉霉素则能抑制趋化因子的产生和S.肺炎这些结果为RSV感染的治疗提供了新的途径。

项目成果

Type-III IFN is the mainIFN induced by RSV in NEC

III型干扰素是RSV在NEC中诱导的主要干扰素

• 发表时间: 2011
• 期刊: Virus Res
• 影响因子: 5
• 作者: 佐藤佳;三沢尚子;福原充子;岩見真吾;伊藤守;小柳義夫;Okabayashi et al.,
• 通讯作者: Okabayashi et al.,

Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells

• DOI: 10.1007/s00795-013-0024-1
• 发表时间: 2013-12-01
• 期刊: MEDICAL MOLECULAR MORPHOLOGY
• 影响因子: 1.8
• 作者: Fuchimoto, Jun;Kojima, Takashi;Sawada, Norimasa
• 通讯作者: Sawada, Norimasa

Clarithromycin suppresses human RSV infection -induced Streptococcus pneumonia adhesion and cytokine production in a pulmonary epithelial cell line

克拉霉素抑制肺上皮细胞系中人 RSV 感染诱导的肺炎链球菌粘附和细胞因子产生

• 发表时间: 2012
• 期刊: Mediators Inflamm
• 作者: Yokota SI;Okabayashi T;Hirakawa S;Tsutsumi H;Fujii N
• 通讯作者: Fujii N

NF-kB regulates replication of RSV iin NEC

NF-kB 调节 NEC 中 RSV 的复制

• 发表时间: 2011
• 期刊: Mol. Miol. Cell
• 作者: 長嶋茂雄;高橋雅春;吉林台;西澤勉;小林富成;岡本宏明;Masaki et al.,
• 通讯作者: Masaki et al.,