Producing mechanism and function of IFN-λin nasal epithelial cells infected with RS-virus.

我们报道了干扰素-λ是RSV感染的鼻上皮细胞诱导的主要干扰素。而呼吸道合胞病毒感染儿童鼻分泌物中IFN-λ与IFN-β含量差异无统计学意义。鼻分泌物中检出肺炎链球菌及趋化因子。啤酒花苦酸的主要成分Humuleone抑制RSV复制和趋化因子的产生，抗菌药物Clarithromycis抑制趋化因子的产生和肺炎链球菌受体PAF的表达。这些结果为RSV感染的治疗提供了新的途径。

We reported that IFN-λ is the predominant IFN induced from RSV infected nasal epithelial cells. However, there were no-significant difference between IFN-λand IFN-βin nasal discharge of RSV-infected child. Streptococcus pneumonia and chemokines in nasal discharge were detected. Humuleone, the main constituent of hop bitter acids, inhibited RSV replication and chemokines production, and Clarithromycis, antimicrobial agent, inhibited chemokines production and PAF expressioni, which is the receptor of S. pneumonia. These results suggested new treatment approach to RSV infection.